Oncopathology Update

3.4.18

Grade Group in reporting of prostate acinar adenocarcinoma:

The 9 Gleason scores (2-10) have been variably lumped into different groups for prognosis and patient management purposes. Epstein and associates proposed grouping scores into 5 prognostic categories, grade groups 1-5.
This grade grouping, shown below in the table, strongly correlate with biochemical recurrence and have been incorporated into the new Partin tables.
At the 2014 ISUP Consensus Conference, details of this prognostic system were clarified and it was recommended for usage together with the Gleason system.
This grade grouping has also been subsequently validated by other independent studies in surgical and radiation cohorts show significant correlation with survival.
The new grade grouping has been endorsed in the 2016 WHO classification.
The grade grouping has also been endorsed by ISUP and is referred to as ISUP grade in some publications. Like Gleason scoring in needle biopsies, the grade group can be applied at core, specimen, or case levels.

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