Papillary Thyroid Ca Criteria in Cytology

Papillary Thyroid Ca Criteria in Cytology (Kini)

5 criteria "Definite"; 4 criteria "Suspicious"; 3 criteria "Follicular Lesion"

Adequate Specimen: 6 clusters of 10-15 cells

1 Syncytial tissue fragments
2 Enlarge nuclei with fine dusty chromatin
3 Multiple micro and or macro nucleoli
4 Intranuclear inclusions
5 Nuclear grooves

Papillary Thyroid Ca Diagnostic Criteria in Histology

4 Major or (3 Major + 4 Minor required)

Major Criteria
1 Nuclei oval (not rounded)
2 Nuclei crowded, manifesting as lack of polarization in cells lining a follicle and overlapping nuclei
3 Pale chromatin esp. at the edge of the tissue where well-fixed
4 Psammoma bodies

Minor Criteria
1 Abortive papillae
2 Elongated or irregular follicles
3 Dark staining colloid
4 Rarely nuclear pseudo inclusion
5 Multinucleated histiiocytes in lumens of follicles
6 Grooves


Ref:
1 Chan JKC Strict criteria should be applied in the diagnosis of encapsulated follicular variant of papillay thyroid ca. AJCP 2002;117:16-18
2 Balock ZW, LiVolsi VA Follicular-patterned lesions of the thyroid. AJCP{ 2002;117:143-150